Week 16 involves an in depth with a “Monday Evening Soccer” matchup that includes the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6).
The 49ers have clinched a playoff berth within the NFC Playoffs—the Detroit Lions can solely hope to tie their file, and San Francisco holds the tie-breaker, in order that they’re in—however they’re nonetheless totally within the hunt for seeding and nonetheless have a shot at profitable their division. At present, the 49ers are a half-game behind the Rams and a game-and-a-half behind the Seahawks within the NFC West.
In the meantime, the Colts presently sit within the No. 8 spot within the AFC Playoff image and third of their division. For Indianapolis, this can be a close to must-win sport for them, as they’re presently a game-and-a-half behind the Texans, who presently maintain the No. 7 spot within the AFC Playoffs and are additionally in second place within the AFC South. If the Colts win this sport, they’ll have a 6% likelihood of creating the playoffs, whereas a loss drops them right down to 1%, per the Athletic’s (New York Occasions’) playoff simulator.
From a rooting perspective, as a result of the Lions can not catch the 49ers within the NFC Playoff seeding, there’s nothing actually to root for on this sport.
Right here’s the way to watch tonight’s sport:
When: Monday, December 22, 2025 — 8:15 p.m. ETWhere: Lucas Oil Stadium in Indianapolis, IndianaTV: ESPNAnnouncers: Joe Buck and Troy Aikman, with discipline reporters Lisa Salters and Laura RutledgeOnline streaming: ESPN+, Hulu + Reside TV, NFL+
No Manningcast this week: The Manningcast returns in Week 18
